The locus C11orf30 increases susceptibility to poly-sensitization.

Authors :: Amaral AF
Minelli C
Guerra S
Wjst M
Probst-Hensch N
Pin I
Svanes C
Janson C
Heinrich J
Jarvis DL
Source :: Allergy [Allergy] 2015 Mar; Vol. 70 (3), pp. 328-33. Date of Electronic Publication: 2014 Dec 24.
Publication Year :: 2015
Abstract: A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)