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Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2015 Mar; Vol. 28 (3), pp. 319-29. Date of Electronic Publication: 2014 Dec 29. - Publication Year :
- 2015
-
Abstract
- Background: Livers with moderate (30-60%) macrovesicular steatosis have been associated with poor outcome after transplantation. Aim of this study was to examine the outcome after transplantation of livers with moderate macrovesicular steatosis when the cold ischemia time (CIT) is kept very short.<br />Methods: Postoperative outcome of 19 recipients of a moderate steatotic liver were compared with a matched control group of 95 recipients of a nonsteatotic liver graft (1:5 ratio). We studied graft/patient survival rates, incidences of primary nonfunction, postoperative complications (classified according to the Clavien-Dindo classification), first-week postoperative hepatic injury serum markers (AST/ALT), and liver function tests (PT time/bilirubin/lactate). In addition, we studied reversal of graft steatosis in follow-up biopsies.<br />Results: Median CIT in livers with moderate steatosis and in controls was below 8 h in both groups. Although short- and long-term patient/graft survival rates and results of liver function tests were similar, serum markers of hepatic injury and postoperative complications (especially grade IVa) were significantly higher in recipients of a moderate steatotic liver. Reversal of steatosis was seen in 9 of the 11 (82%) recipients with follow-up liver biopsies.<br />Conclusion: Despite the association with severe postoperative complications, moderate macrovesicular steatotic livers can be used successfully for transplantation if the CIT is kept very short.<br /> (© 2014 Steunstichting ESOT.)
- Subjects :
- Adult
Aged
Biopsy
Fatty Liver mortality
Fatty Liver pathology
Female
Follow-Up Studies
Graft Survival
Humans
Liver Failure mortality
Liver Failure pathology
Male
Middle Aged
Netherlands epidemiology
Postoperative Period
Retrospective Studies
Severity of Illness Index
Survival Rate trends
Time Factors
Young Adult
Cold Ischemia methods
Fatty Liver surgery
Liver pathology
Liver Failure surgery
Liver Transplantation
Tissue Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 25545740
- Full Text :
- https://doi.org/10.1111/tri.12504