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Benefits of timely basal insulin control in patients with type 2 diabetes.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2015 Mar; Vol. 29 (2), pp. 295-301. Date of Electronic Publication: 2014 Dec 05. - Publication Year :
- 2015
-
Abstract
- Worldwide, both underdiagnosis and undertreatment leave many patients exposed to long periods of hyperglycemia and contribute to irreversible diabetes complications. Early glucose control reduces the risk of both macrovascular and microvascular complications, while tight control late in diabetes has little or no macrovascular benefit. Insulin therapy offers the most potent antihyperglycemic effect of all diabetes agents, and has a unique ability to induce diabetes remission when used to normalize glycemia in newly diagnosed patients. When used as a second-line therapy, basal insulin is more likely to safely and durably maintain A1C levels ≤7% than when insulin treatment is delayed. The use of basal insulin analogs is associated with a reduced risk of hypoglycemia and weight gain compared to NPH insulin and pre-mixed insulin. Patient self-titration algorithms can improve glucose control while decreasing the burden on office staff. Finally, recent data suggest that addition of incretin agents to basal insulin may improve glycemic control with very little, if any increased risk of hypoglycemia or weight gain.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 physiopathology
Disease Progression
Drug Therapy, Combination adverse effects
Humans
Hypoglycemia chemically induced
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents adverse effects
Insulin administration & dosage
Insulin adverse effects
Insulin analogs & derivatives
Overweight chemically induced
Overweight complications
Overweight prevention & control
Practice Guidelines as Topic
Quality of Life
Diabetes Complications prevention & control
Diabetes Mellitus, Type 2 drug therapy
Hyperglycemia prevention & control
Hypoglycemia prevention & control
Hypoglycemic Agents therapeutic use
Insulin therapeutic use
Precision Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 25536866
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2014.11.018