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The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease.

Authors :
Meadowcroft MD
Peters DG
Dewal RP
Connor JR
Yang QX
Source :
NMR in biomedicine [NMR Biomed] 2015 Mar; Vol. 28 (3), pp. 297-305. Date of Electronic Publication: 2014 Dec 22.
Publication Year :
2015

Abstract

Dysregulation of neural iron is known to occur during the progression of Alzheimer's disease. The visualization of amyloid-beta (Aβ) plaques with MRI has largely been credited to rapid proton relaxation in the vicinity of plaques as a result of focal iron deposition. The goal of this work was to determine the relationship between local relaxation and related focal iron content associated with Aβ plaques. Alzheimer's disease (n=5) and control tissue (n=3) sample slices from the entorhinal cortex were treated overnight with the iron chelator deferoxamine or saline, and microscopic gradient-echo MRI datasets were taken. Subsequent to imaging, the same slices were stained for Aβ and iron, and then compared with regard to parametric R2 * relaxation maps and gradient-echo-weighted MR images. Aβ plaques in both chelated and unchelated tissue generated MR hypo-intensities and showed relaxation rates significantly greater than the surrounding tissue. The transverse relaxation rate associated with amyloid plaques was determined not to be solely a result of iron load, as much of the relaxation associated with Aβ plaques remained following iron chelation. The data indicate a dual relaxation mechanism associated with Aβ plaques, such that iron and plaque composition synergistically produce transverse relaxation.<br /> (Copyright © 2014 John Wiley & Sons, Ltd.)

Details

Language :
English
ISSN :
1099-1492
Volume :
28
Issue :
3
Database :
MEDLINE
Journal :
NMR in biomedicine
Publication Type :
Academic Journal
Accession number :
25530083
Full Text :
https://doi.org/10.1002/nbm.3247