Back to Search
Start Over
The development of dose-dense adjuvant chemotherapy.
- Source :
-
The breast journal [Breast J] 2015 Jan-Feb; Vol. 21 (1), pp. 42-51. Date of Electronic Publication: 2014 Dec 22. - Publication Year :
- 2015
-
Abstract
- Dose-dense chemotherapy has made a significant contribution to the adjuvant treatment of breast cancer. One way of achieving dose-density is through the use of sequential therapy with noncross resistant therapies to cause cell kill in tumors composed of heterogeneous cells. Another way to achieve this is to shorten the inter-treatment interval to minimize the re-growth of tumor cells, thus allowing for more effective cell killing. Several trials have tested this concept with the majority demonstrating improved efficacy with a dose-density when compared with the traditional schedule. One such notable trial was CALGB 9741 that showed that when dose size and cycle numbers were kept constant, shortening the interval between each chemotherapy dose, with granulocyte-colony stimulating factor support, significantly improved disease-free and overall survival. This important and practice-changing trial led to the wide adoption of dose-dense chemotherapy and formed the basis of many subsequent studies, including allowing for the addition of biologic and targeted agents with excellent safety profile.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Breast Neoplasms drug therapy
Chemotherapy, Adjuvant methods
Clinical Trials as Topic
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Filgrastim
Granulocyte Colony-Stimulating Factor
Hematologic Agents administration & dosage
History, 20th Century
History, 21st Century
Humans
Recombinant Proteins
Antineoplastic Agents administration & dosage
Breast Neoplasms history
Chemotherapy, Adjuvant history
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4741
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The breast journal
- Publication Type :
- Academic Journal
- Accession number :
- 25530009
- Full Text :
- https://doi.org/10.1111/tbj.12364