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Clinical significance of soluble CD26 in malignant pleural mesothelioma.
- Source :
-
PloS one [PLoS One] 2014 Dec 19; Vol. 9 (12), pp. e115647. Date of Electronic Publication: 2014 Dec 19 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- There is no established single diagnostic marker for malignant pleural mesothelioma (MPM). CD26 is a 110 kDa, multifunctional, membrane-bound glycoprotein that has dipeptidyl peptidase IV (DPPIV) enzyme activity. The aim of this study was to evaluate the clinical significance of soluble CD26 (sCD26) in patients with MPM. The study included 80 MPM patients, 79 subjects with past asbestos exposure (SPE), and 134 patients with other benign pleural diseases (OPD) that were included as a control group. sCD26 levels and DPPIV activity in serum and/or pleural fluid were determined using an ELISA kit. Serum sCD26 levels and DPPIV enzyme activity in patients with MPM were significantly decreased compared with those in the SPE group (P = 0.000). The level of serum sCD26 was significantly decreased in patients with advanced stages of MPM compared with those with earlier stages (P = 0.047). The median OS of patients with MPM who had higher DPPIV enzyme activity was significantly longer than that of those with lower DPPIV enzyme activity (P = 0.032). The sCD26 levels in the pleural fluid of MPM patients with an epithelioid subtype were significantly increased compared with the OPD cohort (P = 0.012). Moreover, DPPIV enzyme activity in the pleural fluid of patients with MPM with an epithelioid subtype were significantly increased compared with those in the OPD cohort (P = 0.009). Patients with MPM who had lower specific DPPIV activity, determined as DPPIV/sCD26, showed significantly prolonged survival compared with those with higher specific DPPIV activity (P = 0.028). Serum sCD26 and DPPIV enzyme activity appear to be useful biomarkers for differentiating patients with MPM from SPE. The sCD26 levels or DPPIV enzyme activity in pleural fluid appear to be biomarkers in patients with an epithelioid subtype of MPM. DPPIV activity in serum or pleural fluid appears to be predictive for the prognosis of patients with MPM.
- Subjects :
- Aged
Biomarkers, Tumor blood
Diagnosis, Differential
Dipeptidyl Peptidase 4 blood
Female
Humans
Lung Neoplasms blood
Lung Neoplasms enzymology
Male
Mesothelioma blood
Mesothelioma enzymology
Mesothelioma, Malignant
Middle Aged
Pleura pathology
Pleural Neoplasms blood
Pleural Neoplasms enzymology
Prognosis
Survival Analysis
Biomarkers, Tumor metabolism
Dipeptidyl Peptidase 4 metabolism
Lung Neoplasms pathology
Mesothelioma pathology
Pleura enzymology
Pleural Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25526639
- Full Text :
- https://doi.org/10.1371/journal.pone.0115647