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[Real-time MRI/US fusion-guided biopsy in biopsy-naïve and pre-biopsied patients with suspicion for prostate cancer].
- Source :
-
Aktuelle Urologie [Aktuelle Urol] 2015 Jan; Vol. 46 (1), pp. 34-8. Date of Electronic Publication: 2014 Dec 17. - Publication Year :
- 2015
-
Abstract
- Background: Magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy detects more prostate cancer (PCa) than transrectal US (TRUS)-guided biopsy in patients with an indication for prostate re-biopsy. The aim of this study was a) to compare the detection rates of MRI/US fusion-guided biopsy with conventional TRUS in a double centre cohort and b) to investigate the influence of the number of pre-biopsies on the PCa detection rate.<br />Material and Methods: In the period from January 2012 to July 2014, 310 consecutive patients gave written informed consent and underwent 3 Tesla MRI scans of the prostate. All patients had at least one PCa suspicious lesion in the MRI and were biopsied by MRI/US fusion followed by a conventional 10-core biopsy of the prostate. Detection rates based on technique, Gleason score and number of pre-biopsies were calculated.<br />Results: The overall detection rate of the study was 51% (158 patients). Among these 158 patients a histopathological Gleason score of 6 was detected in 60 patients (38%), a Gleason score of 7 in 54 patients (34%) and a Gleason score≥8 in 44 patients (28%). MRI/US fusion-guided biopsy detected 110 (69.7%) of the overall detected 158 PCa. TRUS-guided biopsy detected a higher rate of Gleason score 6 (54%) and a lower rate of Gleason score≥8 (15%) lesions in comparison to 38% Gleason 6 and 28% Gleason≥8 in the MRI/US fusion-guided biopsy, respectively. Furthermore, a lower Gleason score was observed in patients with more than one pre-biopsy. The detection rate in biopsy-naïve patients undergoing MRI/US fusion was 75% (40 patients) among 75% detected Gleason score≥7.<br />Conclusion: MRI/US fusion-guided biopsy detected more PCa and also more clinically significant cancer than conventional TRUS. In our cohort patients with more than one pre-biopsy showed lower Gleason scores. The included patients with an initial MRI/US fusion-guided biopsy should be further investigated.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cohort Studies
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Humans
Male
Middle Aged
Neoplasm Grading
Prospective Studies
Prostate pathology
Sensitivity and Specificity
Image-Guided Biopsy methods
Magnetic Resonance Imaging methods
Magnetic Resonance Imaging, Interventional methods
Multimodal Imaging methods
Prostatic Neoplasms pathology
Ultrasonography methods
Subjects
Details
- Language :
- German
- ISSN :
- 1438-8820
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Aktuelle Urologie
- Publication Type :
- Academic Journal
- Accession number :
- 25519051
- Full Text :
- https://doi.org/10.1055/s-0034-1395563