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[Cryopreservation of testicular tissue in children].
- Source :
-
Bulletin de l'Academie nationale de medecine [Bull Acad Natl Med] 2013 Apr-May; Vol. 197 (4-5), pp. 877-86; discussion 886. - Publication Year :
- 2013
-
Abstract
- The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.
- Subjects :
- Adolescent
Animals
Antineoplastic Agents adverse effects
Child
Child, Preschool
Humans
Infant
Infertility, Male etiology
Male
Neoplasms therapy
Radiotherapy adverse effects
Seminiferous Tubules
Spermatogonia
Testis drug effects
Testis radiation effects
Transplantation, Autologous
Transplantation, Heterotopic
Cryopreservation methods
Fertility Preservation methods
Infertility, Male prevention & control
Replantation
Testis surgery
Subjects
Details
- Language :
- French
- ISSN :
- 0001-4079
- Volume :
- 197
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Bulletin de l'Academie nationale de medecine
- Publication Type :
- Academic Journal
- Accession number :
- 25518156