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[Cryopreservation of testicular tissue in children].

Authors :
Rives N
Milazzo JP
Travers A
Arkoun B
Bironneau A
Sibert L
Liard-Zmuda A
Marie-Cardine A
Schneider P
Vannier JP
Macé B
Source :
Bulletin de l'Academie nationale de medecine [Bull Acad Natl Med] 2013 Apr-May; Vol. 197 (4-5), pp. 877-86; discussion 886.
Publication Year :
2013

Abstract

The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.

Details

Language :
French
ISSN :
0001-4079
Volume :
197
Issue :
4-5
Database :
MEDLINE
Journal :
Bulletin de l'Academie nationale de medecine
Publication Type :
Academic Journal
Accession number :
25518156