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Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males.
- Source :
-
Public health nutrition [Public Health Nutr] 2015 Aug; Vol. 18 (12), pp. 2211-9. Date of Electronic Publication: 2014 Dec 17. - Publication Year :
- 2015
-
Abstract
- Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city.<br />Design: An intervention trial.<br />Setting: Shenzhen City, Guangdong Province, China.<br />Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.<br />Results: For the survey, there was no significant difference (P>0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P=0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P<0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men.<br />Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.
- Subjects :
- Adolescent
Adult
Aged
Asian People
Biological Availability
Body Mass Index
China
Cross-Sectional Studies
Dose-Response Relationship, Drug
Humans
Life Style
Male
Middle Aged
Parathyroid Hormone blood
Polymorphism, Single Nucleotide
Receptors, Calcitriol blood
Receptors, Calcitriol genetics
Vitamin D administration & dosage
Vitamin D pharmacokinetics
Young Adult
Dietary Supplements
Insulin Resistance
Obesity blood
Parathyroid Hormone metabolism
Vitamin D blood
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2727
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Public health nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 25517289
- Full Text :
- https://doi.org/10.1017/S1368980014002845