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Pyrazolopyrimidines in 'all-natural' products for erectile dysfunction treatment: the unreliable quality of dietary supplements.
- Source :
-
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2015; Vol. 32 (2), pp. 127-40. Date of Electronic Publication: 2014 Dec 17. - Publication Year :
- 2015
-
Abstract
- A herbal food supplement advertised as a potency pill was screened for the presence of PDE5 inhibitors. The resulting signals were characterised by UV, LC-MS in ESI-negative mode, and NMR spectroscopy using 1D and 2D experiments. Several substances were identified, bearing the basic chemical structure of sildenafil, but were not supposed to exhibit PDE5 inhibition. These compounds may be process-related impurities or by-products of different reaction steps in the synthesis of PDE5 analogues. As they were found to be present in different capsules at different concentrations, this is an example of the unreliable quality of dietary supplements.
- Subjects :
- Biological Products chemistry
Biological Products isolation & purification
Cyclic Nucleotide Phosphodiesterases, Type 5 metabolism
Humans
Male
Molecular Structure
Phosphodiesterase 5 Inhibitors chemistry
Phosphodiesterase 5 Inhibitors isolation & purification
Pyrazoles chemistry
Pyrazoles isolation & purification
Pyrimidines chemistry
Pyrimidines isolation & purification
Structure-Activity Relationship
Biological Products pharmacology
Dietary Supplements standards
Erectile Dysfunction drug therapy
Phosphodiesterase 5 Inhibitors pharmacology
Pyrazoles pharmacology
Pyrimidines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-0057
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
- Publication Type :
- Academic Journal
- Accession number :
- 25517174
- Full Text :
- https://doi.org/10.1080/19440049.2014.992980