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(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
- Source :
-
ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Nov 25; Vol. 5 (12), pp. 1334-9. Date of Electronic Publication: 2014 Nov 25 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- S1P1 is a validated target for treatment of autoimmune disease, and functional antagonists with superior safety and pharmacokinetic properties are being sought as second generation therapeutics. We describe the discovery and optimization of (7-benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acids as potent, centrally available, direct acting S1P1 functional antagonists, with favorable pharmacokinetic and safety properties.
Details
- Language :
- English
- ISSN :
- 1948-5875
- Volume :
- 5
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- ACS medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 25516794
- Full Text :
- https://doi.org/10.1021/ml500422m