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Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation.
- Source :
-
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Jul; Vol. 35 (7), pp. 1893-901. Date of Electronic Publication: 2015 Jan 20. - Publication Year :
- 2015
-
Abstract
- Background & Aims: Chronic kidney disease (CKD) is a common complication after liver transplantation. Kidney biopsies cannot be easily performed before liver transplantation to predict patients at high risk for CKD. The aim of our study was to determine whether pre-, peri- and post-transplant factors, as well as peptides present in preliver transplant urine samples were associated with loss in kidney function at 6 months post-transplantation using proteome analysis.<br />Methods: Eighty patients who underwent a liver transplantation and that had pretransplant glomerular filtration rate (GFR) value of ≥60 mL/min/1.73 m² (MDRD) were included in the study.<br />Results: GFR decreased significantly after transplantation. At month 6 post-transplantation, 40 patients displayed a CKD, i.e. eGFR of <60 mL/min/1.73 m², while the other 40 patients did not. Although thousands of peptides were identified, none was significantly associated with the development of CKD at 6 months after liver transplantation. Moreover, using a urinary peptidome classifier to detect preexisting CKD, no difference was found in CKD scores between the 2 groups. After analysis of a large number of pre-, peri- and post-transplant parameters, viral hepatitis as a cause for liver transplantation was the sole independent predictive factor for CKD. No difference in peptides with differential urinary abundance between patients who received a graft for virus related liver disease vs. all other causes of liver disease was observed.<br />Conclusion: Urinary peptidome analysis before liver transplantation failed to identify a peptide pattern associated with the development of CKD at 6 months after liver transplantation.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Biomarkers urine
Female
Glomerular Filtration Rate
Humans
Kidney physiopathology
Liver Diseases complications
Liver Diseases diagnosis
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Proteinuria complications
Proteinuria urine
Renal Insufficiency, Chronic diagnosis
Renal Insufficiency, Chronic physiopathology
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Urinalysis
Kidney metabolism
Liver Diseases surgery
Liver Transplantation adverse effects
Proteinuria diagnosis
Proteomics methods
Renal Insufficiency, Chronic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-3231
- Volume :
- 35
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 25515948
- Full Text :
- https://doi.org/10.1111/liv.12763