Asymmetric dual-reagent catalysis: Mannich-type reactions catalyzed by ion pair.

Authors :: Wang HY
Zhang K
Zheng CW
Chai Z
Cao DD
Zhang JX
Zhao G
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Feb 02; Vol. 54 (6), pp. 1775-9. Date of Electronic Publication: 2014 Dec 16.
Publication Year :: 2015
Abstract: The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied to Mannich-type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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