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[State of antioxidant system of rat thymocytes in experimental ulcerogenesis].
- Source :
-
Ukrainian biochemical journal [Ukr Biochem J] 2014 Jul-Aug; Vol. 86 (4), pp. 126-31. - Publication Year :
- 2014
-
Abstract
- Features of free radical processes and their impact on the implementation of immunocompetent cells of their functions under conditions of peptic ulcer are insufficiently studied today. Reduced activity of catalase 1.7 and 3.4 times and that of glutathione peroxidise ~ 2.0 times, accordingly, were observed in both models of gastric ulceration (stress ulcer and ethanol one). Enzymatic activity of superoxide dismutase decreased 1.5 times and activity of glutathione transferase increased 1.8 times in the stress model in contrast to the ethanol model of stomach ulcer. Obtained results indicate the exhaustion of antioxidant system in rats' thymocytes under experi- mental ulcerogenesis. These data confirm complex negative effect of ulcer on the organism.
- Subjects :
- Adaptation, Physiological
Animals
Catalase metabolism
Disease Models, Animal
Female
Glutathione Peroxidase metabolism
Glutathione Transferase metabolism
Male
Rats
Restraint, Physical
Stomach Ulcer etiology
Superoxide Dismutase metabolism
Antioxidants metabolism
Stomach Ulcer enzymology
Stress, Psychological complications
Thymocytes enzymology
Subjects
Details
- Language :
- Ukrainian
- ISSN :
- 2409-4943
- Volume :
- 86
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Ukrainian biochemical journal
- Publication Type :
- Academic Journal
- Accession number :
- 25509191