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A comparison of single doses of lisinopril and enalapril in hypertension.

Authors :
Dews I
Wiseman WT
al-Khawaja I
Stephens J
VandenBurg M
Source :
Journal of human hypertension [J Hum Hypertens] 1989 Jun; Vol. 3 Suppl 1, pp. 35-9.
Publication Year :
1989

Abstract

Sixteen patients with mild to moderate hypertension were studied in a double-blind crossover comparison of single oral doses of lisinopril 10 mg and enalapril 10 mg. Both drugs caused a marked fall in blood pressure (BP) with a clinically useful effect persisting for 24 h postdose and with no significant difference between treatments in this respect. The time to minimum systolic BP was 2 h (95% confidence limits 0-19 h) longer for lisinopril. The fall in ACE activity at 24 h was 18.5 (8.2-28.8) U/l greater for lisinopril. We conclude that, within the limits of this small study, lisinopril appears to be as effective as enalapril in lowering BP and that it may have a slower onset of action that could be clinically valuable.

Details

Language :
English
ISSN :
0950-9240
Volume :
3 Suppl 1
Database :
MEDLINE
Journal :
Journal of human hypertension
Publication Type :
Academic Journal
Accession number :
2550644