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MORC1 represses transposable elements in the mouse male germline.
- Source :
-
Nature communications [Nat Commun] 2014 Dec 12; Vol. 5, pp. 5795. Date of Electronic Publication: 2014 Dec 12. - Publication Year :
- 2014
-
Abstract
- The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other DNA-methylated and silent genes. MORC1-deficient mice were previously found to display male-specific germ cell loss and infertility. Here we show that MORC1 is responsible for transposon repression in the male germline in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homologue DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of transposons, and this is associated with failed transposon silencing at these sites. Our results identify MORC1 as an important new regulator of the epigenetic landscape of male germ cells during the period of global de novo methylation.
- Subjects :
- Animals
Cell Nucleus metabolism
Cell Nucleus ultrastructure
DNA (Cytosine-5-)-Methyltransferases genetics
DNA (Cytosine-5-)-Methyltransferases metabolism
DNA Methylation
Embryo, Mammalian
Male
Mice
Mice, Transgenic
Nuclear Proteins metabolism
RNA, Small Interfering genetics
RNA, Small Interfering metabolism
Spermatozoa cytology
Spermatozoa growth & development
Time Factors
DNA Transposable Elements
Epigenesis, Genetic
Nuclear Proteins genetics
Spermatozoa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 25503965
- Full Text :
- https://doi.org/10.1038/ncomms6795