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Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy.
- Source :
-
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2015 Feb; Vol. 81 (2), pp. 141-4. Date of Electronic Publication: 2014 Nov 28. - Publication Year :
- 2015
-
Abstract
- We collected nasal, axilla, and groin swabs from 252 adult patients from 2 nephrology centers in Hong Kong. Staphylococcus lugdunensis carriage was detected in 51.6% patients (groin, 39.3%; axilla, 19.8%; nose, 17.9%). The carriage rates of methicillin-sensitive S. lugdunensis and methicillin-resistant S. lugdunensis (MRSL) were 46.0% and 8.3%, respectively. Independent risk factors for S. lugdunensis carriage included male sex (odds ratio [OR], 4.4), hemodialysis (OR, 2.2), and aged 18-50years (OR, 2.4). The isolates belonged to 10 pulsotype clusters (n=129) and 8 singletons (n=8). All MRSL and most gentamicin- and tetracycline-resistant strains were found in a predominating sequence type 3 clone, designated HKU1, which accounted for 51.8% of all colonizing S. lugdunensis strains. The 21 MRSL isolates had SCCmec type V (n=18), type IV (n=2), and type I (n=1). The finding highlights the potential for dissemination of multidrug resistance through successful S. lugdunensis clones.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Carrier State microbiology
Cross-Sectional Studies
Electrophoresis, Gel, Pulsed-Field
Female
Genotype
Hong Kong epidemiology
Humans
Male
Middle Aged
Molecular Epidemiology
Molecular Typing
Risk Factors
Staphylococcal Infections microbiology
Staphylococcus lugdunensis classification
Staphylococcus lugdunensis drug effects
Staphylococcus lugdunensis genetics
Young Adult
Carrier State epidemiology
Methicillin Resistance
Renal Replacement Therapy
Staphylococcal Infections epidemiology
Staphylococcus lugdunensis isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0070
- Volume :
- 81
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diagnostic microbiology and infectious disease
- Publication Type :
- Academic Journal
- Accession number :
- 25498337
- Full Text :
- https://doi.org/10.1016/j.diagmicrobio.2014.10.004