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Vitamin D and tuberculosis: a multicenter study in children.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2014 Dec 11; Vol. 14, pp. 652. Date of Electronic Publication: 2014 Dec 11. - Publication Year :
- 2014
-
Abstract
- Background: The aim of this study is to evaluate vitamin D levels in children with latent and active TB compared to healthy controls of the same age and ethnical background.<br />Methods: A multicenter observational study has been conducted in three tertiary care paediatric centres: Anna Meyer Children's University Hospital, Florence, Italy; Evelina London Children's Hospital, London, United Kingdom and Great Ormond Street Hospital, London, United Kingdom. Vitamin D was considered deficient if the serum level was <25 nmol/L, insufficient between 25 and 50 nmol/L and sufficient for a level >50 nmol/L.<br />Results: The study population included 996 children screened for TB, which have been tested for vitamin D. Forty-four children (4.4%) had active TB, 138 (13.9%) latent TB and 814 (81.7%) were controls. Our study confirmed a high prevalence of hypovitaminosis D in the study population. A multivariate analysis confirmed an increased risk of hypovitaminosis D in children with latent and active TB compared to controls [(P = 0.018; RR = 1.61; 95% CI: 1.086-2.388), (P < 0.0001; RR = 4.587; 95% CI:1.190-9.608)].<br />Conclusions: Hypovitaminosis D was significantly associated with TB infection in our study. Further studies are needed to evaluate a possible role of vitamin D in the treatment and prevention of tuberculosis in children.
- Subjects :
- Adolescent
Biomarkers blood
Case-Control Studies
Child
Child, Preschool
Female
Humans
Male
Prevalence
Prospective Studies
Retrospective Studies
Vitamin D Deficiency blood
Vitamin D Deficiency diagnosis
Vitamin D Deficiency epidemiology
Tuberculosis complications
Vitamin D blood
Vitamin D Deficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25494831
- Full Text :
- https://doi.org/10.1186/s12879-014-0652-7