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Total synthesis of elastin peptide using high pressure-liquid phase synthesis assisted by a soluble tag strategy.

Authors :
Okada Y
Hosoya S
Suzuki H
Chiba K
Source :
Organic letters [Org Lett] 2014 Dec 19; Vol. 16 (24), pp. 6448-51. Date of Electronic Publication: 2014 Dec 10.
Publication Year :
2014

Abstract

A highly aggregating elastin peptide was prepared efficiently using a high pressure-liquid phase synthesis approach assisted by a soluble tag strategy. Two standard syringes were connected to each other to construct a reactor. This simple reactor was used to apply high pressure to the highly viscous reaction mixture thereby maintaining its fluidity. The reactions were completely inhibited due to aggregation when conducted in a standard flask reactor, whereas our high pressure approach accelerated the couplings to realize complete conversion within 5-7 min. All steps were conducted at 0.10 M concentration, affording grams of the desired product.

Details

Language :
English
ISSN :
1523-7052
Volume :
16
Issue :
24
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
25494479
Full Text :
https://doi.org/10.1021/ol5032798