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Total synthesis of elastin peptide using high pressure-liquid phase synthesis assisted by a soluble tag strategy.
- Source :
-
Organic letters [Org Lett] 2014 Dec 19; Vol. 16 (24), pp. 6448-51. Date of Electronic Publication: 2014 Dec 10. - Publication Year :
- 2014
-
Abstract
- A highly aggregating elastin peptide was prepared efficiently using a high pressure-liquid phase synthesis approach assisted by a soluble tag strategy. Two standard syringes were connected to each other to construct a reactor. This simple reactor was used to apply high pressure to the highly viscous reaction mixture thereby maintaining its fluidity. The reactions were completely inhibited due to aggregation when conducted in a standard flask reactor, whereas our high pressure approach accelerated the couplings to realize complete conversion within 5-7 min. All steps were conducted at 0.10 M concentration, affording grams of the desired product.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25494479
- Full Text :
- https://doi.org/10.1021/ol5032798