Back to Search
Start Over
Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa.
- Source :
-
PloS one [PLoS One] 2014 Dec 10; Vol. 9 (12), pp. e110393. Date of Electronic Publication: 2014 Dec 10 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
- Subjects :
- Africa, Central
Africa, Western
Antitubercular Agents pharmacology
Genotyping Techniques
Mycobacterium tuberculosis isolation & purification
Phylogeny
Retreatment
Retrospective Studies
Tuberculosis drug therapy
Tuberculosis epidemiology
Tuberculosis microbiology
Drug Resistance, Bacterial
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25493429
- Full Text :
- https://doi.org/10.1371/journal.pone.0110393