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Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Dec 07; Vol. 20 (45), pp. 17120-6. - Publication Year :
- 2014
-
Abstract
- Aim: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.<br />Methods: We obtained clinical data on Crohn's disease (CD) (n = 691) and ulcerative colitis (n = 1113) from a tertiary referral medical center between 2005 and 2012. Seventeen patients (2.5%) with CD and 27 patients (2.4%) with ulcerative colitis (UC) were identified as having a familial history of IBD, including the first and second degree relatives. For each control case, three times the number of age-, sex-, and diagnosis year-matched CD and UC patients, without a family history of IBD, were randomly selected in this case control study.<br />Results: There were no significant differences in age or main symptom at diagnosis, extraintestinal manifestation, location/extent, behavior of disease activity, number of hospitalizations, number of operations, operation type, number of relapses, or oral medical treatment between familial and sporadic CD and UC patients. Median (min-max) follow-up periods after diagnosis of familial CD and sporadic CD patients were 84 (24-312) and 36 (8-240) mo, respectively (P = 0.008). Familial CD patients more frequently used anti-tumor necrosis factor (TNF) antibodies compared to sporadic CD patients (17.6% vs 0%, P = 0.014).<br />Conclusion: In conclusion, a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients.
- Subjects :
- Adolescent
Adult
Anti-Inflammatory Agents therapeutic use
Colitis, Ulcerative diagnosis
Colitis, Ulcerative epidemiology
Colitis, Ulcerative immunology
Colitis, Ulcerative therapy
Crohn Disease diagnosis
Crohn Disease epidemiology
Crohn Disease immunology
Crohn Disease therapy
Digestive System Surgical Procedures
Disease Progression
Female
Gastrointestinal Agents therapeutic use
Genetic Predisposition to Disease
Heredity
Hospitalization
Humans
Male
Middle Aged
Pedigree
Phenotype
Recurrence
Registries
Remission Induction
Republic of Korea epidemiology
Retrospective Studies
Risk Factors
Tertiary Care Centers
Treatment Outcome
Tumor Necrosis Factor-alpha antagonists & inhibitors
Young Adult
Colitis, Ulcerative genetics
Crohn Disease genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25493025
- Full Text :
- https://doi.org/10.3748/wjg.v20.i45.17120