Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan.

Authors :: Kayama S
Shigemoto N
Kuwahara R
Oshima K
Hirakawa H
Hisatsune J
Jové T
Nishio H
Yamasaki K
Wada Y
Ueshimo T
Miura T
Sueda T
Onodera M
Yokozaki M
Hattori M
Ohge H
Sugai M
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Feb; Vol. 59 (2), pp. 1356-9. Date of Electronic Publication: 2014 Dec 08.
Publication Year :: 2015
Abstract: We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Subjects :: Enterobacteriaceae drug effects
Imipenem pharmacology
Japan
Microbial Sensitivity Tests
Molecular Sequence Data
Plasmids genetics
Enterobacteriaceae enzymology
beta-Lactamases metabolism

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