Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.

Authors :: Pelizzo G
Mimmi MC
Ballico M
Marotta M
Goruppi I
Peiro JL
Zambaiti E
Costanzo F
Andreatta E
Tonin E
Calcaterra V
Source :: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2016; Vol. 29 (1), pp. 143-7. Date of Electronic Publication: 2014 Dec 23.
Publication Year :: 2016
Abstract: Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.<br />Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.<br />Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.<br />Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.

Subjects :: Humans
Infant
Infant, Newborn
Male
Metabolome
Phenotype
Lung metabolism
Respiratory System Abnormalities metabolism

Language :: English
ISSN :: 1476-4954
Volume :: 29
Issue :: 1
Database :: MEDLINE
Journal :: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Publication Type :: Academic Journal
Accession number :: 25471172
Full Text :: https://doi.org/10.3109/14767058.2014.991708

Full Text Access

Tools