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A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability, and chromatic contrast.
- Source :
-
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2014 Dec 02; Vol. 55 (12), pp. 8583-9. Date of Electronic Publication: 2014 Dec 02. - Publication Year :
- 2014
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Abstract
- Purpose: Past studies have shown that higher macular pigment optical density (MPOD) and lutein (L) and zeaxanthin (Z) supplementation are related to improvements in glare disability, photostress recovery, and chromatic contrast. This study assessed those links using a randomized, double-blind, placebo-controlled design.<br />Methods: The visual effects of 1 year of supplementing L (10 mg/d) and Z (2 mg/d) were investigated. One hundred fifteen young, healthy subjects were recruited and randomized into the study (58 received placebo, 57 L+Z). Several dependent measures were collected at baseline and then once every 3 months: serum L and Z measured by HPLC chromatography; MPOD measured using customized heterochromatic flicker photometry; photostress recovery assessed by measuring the time needed to recover visual acquisition of a grating target after 30 seconds of an intense xenon white flash exposure; glare disability evaluated as the energy in a surrounding annulus necessary to veil a central grating target; and chromatic contrast assessed by measuring thresholds for a yellow grating target superposed on a 460-nm background.<br />Results: Macular pigment optical density increased significantly versus placebo at all eccentricities (10, 30, 60, and 105 minutes from the center of the macula). Serum L and Z also increased significantly by the first follow-up visit (at 3 months), and remained elevated throughout the intervention period of 1 year. Chromatic contrast and photostress recovery time improved significantly versus placebo. Glare disability was correlated with macular pigment density throughout the study period but did not increase significantly in the treated group.<br />Conclusions: Daily supplementation with L+Z resulted in significant increase in serum levels and MPOD and improvements in chromatic contrast and recovery from photostress. These results are consistent with past studies showing that increasing MPOD leads to improved visual performance. (ClinicalTrials.gov number, NCT00909090.).<br /> (Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.)
- Subjects :
- Adaptation, Ocular physiology
Adult
Color Perception physiology
Contrast Sensitivity physiology
Dietary Supplements
Double-Blind Method
Female
Glare
Humans
Light adverse effects
Lutein administration & dosage
Lutein blood
Macula Lutea physiology
Male
Recovery of Function physiology
Retinal Pigments physiology
Stress, Physiological drug effects
Stress, Physiological physiology
Vision Disorders metabolism
Vision Disorders prevention & control
Young Adult
Zeaxanthins administration & dosage
Zeaxanthins blood
Color Perception drug effects
Contrast Sensitivity drug effects
Lutein pharmacology
Recovery of Function drug effects
Vision Disorders physiopathology
Zeaxanthins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5783
- Volume :
- 55
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Investigative ophthalmology & visual science
- Publication Type :
- Academic Journal
- Accession number :
- 25468896
- Full Text :
- https://doi.org/10.1167/iovs.14-15573