Back to Search
Start Over
Effects of oral glutamine during abdominal radiotherapy on chronic radiation enteritis: a randomized controlled trial.
- Source :
-
Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2015 Jan; Vol. 31 (1), pp. 200-4. Date of Electronic Publication: 2014 Sep 02. - Publication Year :
- 2015
-
Abstract
- Objective: Glutamine has been proposed as a preventive treatment for toxicity related to cancer therapies. The aim of this study was to test the efficacy of glutamine in the prevention of radiation enteritis.<br />Methods: A randomized, double-blind, controlled trial was performed including 69 patients who were assigned to receive either glutamine (Gln, 30 g/d) or placebo while they were receiving abdominal radiotherapy. Patients were re-evaluated 1 y after completion of treatment. The presence of chronic enteritis was assessed using the Radiation Therapy Oncology Group scale. Nutritional status was evaluated using subjective global assessment, weight, and bioimpedance. Relative risk (RR) and its confidence interval (CI) were also calculated.<br />Results: The trial initially included 69 patients (34 Gln, 35 placebo), but 11 patients were lost during follow-up (4 Gln, 7 placebo; P = 0.296). Chronic enteritis was developed by 14 % of patients: Gln 16.7 % versus placebo 11.1% (RR = 1.33; 95% CI, 0.35-5.03; P = 0.540). Most cases of enteritis were grade I (75%), with no differences between groups. The stool frequency increased after radiotherapy in patients who received Gln (from 1 ± 1 to 2 ± 2 stools per day, P = 0.012), but remained unchanged with placebo (1 ± 1 stools per day, P = 0.858; difference between groups P = 0.004). There were no differences between the two groups in terms of weight, fat mass, or fat-free mass index, or between patients with enteritis and those without intestinal toxicity.<br />Conclusions: Chronic enteritis is a relatively infrequent phenomenon, and Gln administration during radiotherapy does not exert a protective effect.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Oral
Aged
Chronic Disease
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Double-Blind Method
Female
Gastrointestinal Tract drug effects
Humans
Male
Middle Aged
Neoplasms drug therapy
Neoplasms radiotherapy
Nutritional Status
Enteritis drug therapy
Gastrointestinal Tract radiation effects
Glutamine administration & dosage
Radiotherapy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1244
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition (Burbank, Los Angeles County, Calif.)
- Publication Type :
- Academic Journal
- Accession number :
- 25466666
- Full Text :
- https://doi.org/10.1016/j.nut.2014.08.003