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Folinic acid after MTX as prophylaxis for GVHD in pediatric bone marrow transplantation.
- Source :
-
International journal of hematology [Int J Hematol] 2015 Jan; Vol. 101 (1), pp. 92-8. Date of Electronic Publication: 2014 Dec 03. - Publication Year :
- 2015
-
Abstract
- The effect of folinic acid (FA) on toxicity secondary to the use of methotrexate (MTX) for the prevention of graft-versus-host disease (GVHD) has not been determined. We retrospectively analyzed data from 111 patients who received allogeneic bone marrow transplantation (allo-BMT) in our institution. Fifty patients did not receive FA (non-FA), 37 received FA four times (low dose, LD-FA), and 24 received FA 25 times (high dose, HD-FA) in BMT. No significant differences were observed in the severity of stomatitis after allo-BMT among the three groups while the median of peak value of ALT in HD-FA was significantly lower (P = 0.031). The median time to neutrophil engraftment after allo-BMT in the HD-FA group was significantly shorter than that in the non-FA group (P = 0.034). No significant difference in the median time to neutrophil engraftment was observed between the LD-FA and non-FA groups (P = 0.44). Stepwise multiple regression analysis revealed that the determinants of the shorter duration of neutropenia were transfused total nucleated cell dose (P = 0.001) and the administration of HD-FA (P = 0.036). There was no significant difference in 3-year overall survival among the three groups. Frequent administration of FA may reduce the time to neutrophil engraftment after hematopoietic stem cell transplantation.
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Drug Administration Schedule
Female
Graft vs Host Disease mortality
Humans
Infant
Infant, Newborn
Leucovorin administration & dosage
Leucovorin adverse effects
Male
Methotrexate administration & dosage
Methotrexate adverse effects
Patient Outcome Assessment
Premedication
Retrospective Studies
Transplantation Conditioning
Transplantation, Homologous
Young Adult
Bone Marrow Transplantation adverse effects
Graft vs Host Disease etiology
Graft vs Host Disease prevention & control
Leucovorin therapeutic use
Methotrexate therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 101
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 25465913
- Full Text :
- https://doi.org/10.1007/s12185-014-1712-x