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IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2014 Dec 10; Vol. 16 (6), pp. 736-47. Date of Electronic Publication: 2014 Nov 26. - Publication Year :
- 2014
-
Abstract
- The interferon-induced transmembrane (IFITM) proteins protect cells from diverse virus infections by inhibiting virus-cell fusion. IFITM proteins also inhibit HIV-1 replication through mechanisms only partially understood. We show that when expressed in uninfected lymphocytes, IFITM proteins exert protective effects during cell-free virus infection, but this restriction can be overcome upon HIV-1 cell-to-cell spread. However, when present in virus-producing lymphocytes, IFITM proteins colocalize with viral Env and Gag proteins and incorporate into nascent HIV-1 virions to limit entry into new target cells. IFITM in viral membranes is associated with impaired virion fusion, offering additional and more potent defense against virus spread. Thus, IFITM proteins act additively in both productively infected cells and uninfected target cells to inhibit HIV-1 spread, potentially conferring these proteins with greater breadth and potency against enveloped viruses.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Antigens, Differentiation genetics
CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes virology
Cell Line
Cell Membrane genetics
Cell Membrane metabolism
Cell Membrane virology
Gene Products, gag genetics
Gene Products, gag metabolism
HIV Infections genetics
HIV-1 genetics
Host-Pathogen Interactions
Humans
Membrane Proteins genetics
RNA-Binding Proteins genetics
Virion genetics
Antigens, Differentiation metabolism
HIV Infections metabolism
HIV Infections virology
HIV-1 physiology
Membrane Proteins metabolism
RNA-Binding Proteins metabolism
Virion physiology
Virus Internalization
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 25464829
- Full Text :
- https://doi.org/10.1016/j.chom.2014.11.001