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[Effect of GDNF on the behavior of ASC mice with high hereditary predisposition to catalepsy].
- Source :
-
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2013 Jul-Aug; Vol. 63 (4), pp. 495-501. - Publication Year :
- 2013
-
Abstract
- ASC mice, which were selected for high predisposition to catalepsy, are convenient genetic model for research of central mechanisms related to disorder of motor regulation. The aim of the work was to study the effect of glial cell line-derived neurotrophic factor (GDNF) on catalepsy, locomotor activity, stereotyping behavior in the marble burying test and on the dopamine level in striatum of ASC mice. It was shown that GDNF increased the locomotor activity in the open field, reduced catalepsy expression and stimulated the stereotyping obsessive-compulsive behavior. These changes in behavior were accompanied by increasing dopamine level in striatum.
- Subjects :
- Animals
Catalepsy genetics
Corpus Striatum drug effects
Corpus Striatum metabolism
Genotype
Glial Cell Line-Derived Neurotrophic Factor genetics
Humans
Male
Mice
Motor Activity drug effects
Motor Activity genetics
Stereotyped Behavior drug effects
Stereotyped Behavior physiology
Catalepsy physiopathology
Genetic Predisposition to Disease
Glial Cell Line-Derived Neurotrophic Factor biosynthesis
Subjects
Details
- Language :
- Russian
- ISSN :
- 0044-4677
- Volume :
- 63
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
- Publication Type :
- Academic Journal
- Accession number :
- 25464752
- Full Text :
- https://doi.org/10.7868/s0044467713040102