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Sequential use of mifepristone and misoprostol in treatment of early pregnancy failure appears more effective than misoprostol alone: a retrospective study.
- Source :
-
European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2014 Dec; Vol. 183, pp. 16-9. Date of Electronic Publication: 2014 Oct 14. - Publication Year :
- 2014
-
Abstract
- Objective: Is treatment of early pregnancy failure (EPF) with sequential use of mifepristone and misoprostol more effective than treatment with misoprostol alone?<br />Study Design: In a retrospective cohort study at the Department of Obstetrics and Gynaecology of the Radboud University Medical Centre, 301 women with early pregnancy failure receiving medical treatment between January 2008 and March 2013 were included. Of these, 199 women were pre-treated with 200mg mifepristone (orally) followed by 2 consecutive doses of 800mcg misoprostol (vaginally) and 102 women were treated with 2 consecutive doses of 800mcg misoprostol (vaginally) alone.<br />Results: Complete expulsion was achieved in 66.8% of the women treated with a sequential combination of mifepristone and misoprostol versus 54.9% of the women treated with misoprostol alone. The difference in rates of complete expulsion was 11.9% (P<0.05; 95% CI 0.3-23.6%).<br />Conclusions: Medical treatment of early pregnancy failure with a sequential combination of mifepristone and misoprostol was more effective than treatment with misoprostol alone. Our findings will have to be confirmed by a large prospective multicentre double blinded-randomized trial.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Abortifacient Agents, Nonsteroidal therapeutic use
Abortifacient Agents, Steroidal therapeutic use
Administration, Intravaginal
Administration, Oral
Adult
Cohort Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Mifepristone therapeutic use
Misoprostol therapeutic use
Pregnancy
Retrospective Studies
Treatment Outcome
Abortifacient Agents, Nonsteroidal administration & dosage
Abortifacient Agents, Steroidal administration & dosage
Abortion, Spontaneous drug therapy
Mifepristone administration & dosage
Misoprostol administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7654
- Volume :
- 183
- Database :
- MEDLINE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Publication Type :
- Academic Journal
- Accession number :
- 25461345
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2014.10.010