Mesoporous silica nanoparticles in drug delivery and biomedical applications.

Authors :: Wang Y
Zhao Q
Han N
Bai L
Li J
Liu J
Che E
Hu L
Zhang Q
Jiang T
Wang S
Source :: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2015 Feb; Vol. 11 (2), pp. 313-27. Date of Electronic Publication: 2014 Nov 13.
Publication Year :: 2015
Abstract: In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration.<br />From the Clinical Editor: This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)