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[Epidemiology of Streptococcus pyogenes invasive diseases in France (2007-2011)].
- Source :
-
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2014 Nov; Vol. 21 Suppl 2, pp. S62-8. Date of Electronic Publication: 2014 Nov 13. - Publication Year :
- 2014
-
Abstract
- Group A Streptococcus (GAS) is a human pathogen responsible for a wide range of clinical manifestations. An increase of GAS invasive infections has been described since the mid 1980s. To study the French epidemiology of invasive infections (i) we characterized all GAS invasive strains received at the French National Reference Center for streptococci (CNR-Strep) between 2007 and 2011; (ii) we analyzed the epidemiological data on the corresponding strains. For each strain, emm genotype, superantigen genes and antibiotics susceptibility were determined. Among the 2 603 non redundant invasive GAS strains, 65.1 % (n=1 695) were isolated from blood culture. A streptococcal toxic shock syndrome (STSS) was described in 16.4 % (n=428) of cases, mostly associated with necrotizing fasciitis (NF), pleuropulmonary or osteoarticular infections (p ≤0.001). The case fatality rate was 10.6 %. A total of 102 different emm genotypes were identified. Three emm genotypes predominated, reaching nearly 60 % of the strains: emm 1 (26.7 %), emm 28 (16.4 %), and emm 89 (12.8 %). The proportion of each emm genotype varied according to the year and the age of patients. Among those < 15 years old, the three main genotypes were emm 1 (36.8 %), emm 12 (12.9 %) and emm 4 (9.5 %). The distribution of superantigen genes (SpeA, SpeC and Ssa) was restricted to several emm genotypes. Between 2007 and 2011, the rate of macrolides resistant GAS strains decreased from 7.8 to 5.5 %. emm 1 strains are still the most common especially in most severe clinical manifestations including STSS and NF.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Anti-Bacterial Agents pharmacology
Child
Child, Preschool
Fasciitis, Necrotizing epidemiology
Fasciitis, Necrotizing microbiology
Female
France epidemiology
Genotype
Humans
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests
Middle Aged
Pleuropneumonia epidemiology
Pleuropneumonia microbiology
Shock, Septic epidemiology
Shock, Septic microbiology
Streptococcal Infections drug therapy
Streptococcus pyogenes genetics
Young Adult
Streptococcal Infections epidemiology
Streptococcus pyogenes isolation & purification
Subjects
Details
- Language :
- French
- ISSN :
- 1769-664X
- Volume :
- 21 Suppl 2
- Database :
- MEDLINE
- Journal :
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
- Publication Type :
- Academic Journal
- Accession number :
- 25456682
- Full Text :
- https://doi.org/10.1016/S0929-693X(14)72262-6