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Synthesis and antiviral activities of 3-deaza-3-fluoroaristeromycin and its 5' analogues.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Dec 15; Vol. 22 (24), pp. 6961-4. Date of Electronic Publication: 2014 Nov 06. - Publication Year :
- 2014
-
Abstract
- The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adenosylhomocysteinase antagonists & inhibitors
Adenosylhomocysteinase metabolism
Animals
Antiviral Agents chemistry
Antiviral Agents pharmacology
Cell Line
Chlorocebus aethiops
DNA Viruses drug effects
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
HEK293 Cells
Humans
RNA Viruses drug effects
S-Adenosylhomocysteine chemical synthesis
S-Adenosylhomocysteine pharmacology
Vero Cells
Antiviral Agents chemical synthesis
S-Adenosylhomocysteine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 22
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25456389
- Full Text :
- https://doi.org/10.1016/j.bmc.2014.10.014