Back to Search
Start Over
Metabolic syndrome and risk of cancer: which link?
- Source :
-
Metabolism: clinical and experimental [Metabolism] 2015 Feb; Vol. 64 (2), pp. 182-9. Date of Electronic Publication: 2014 Oct 18. - Publication Year :
- 2015
-
Abstract
- Metabolic syndrome (MS) is characterized by a group of metabolic disturbances which lead to an enhanced risk of cardiovascular diseases and type 2 diabetes mellitus. MS constitutes a preoccupant issue with elevated prevalence in the western countries and is often related with cancer development. Elucidating the mechanisms linking these two pathologies is, therefore, essential to identify potential therapeutic molecular targets for cancer treatment in MS patients. The main goals of this review are, to identify the relation between MS and cancer development, handling specifically each one of the main players on this process: insulin and IGF system, estrogen, pro-inflammatory cytokines and others; and, given that colorectal cancer is one of the most prevalent types of cancer in MS patients, we intend to particularly highlight the mechanisms that promote colorectal cancer development in MS individuals. Finally, we will also focus on the clinical implications of the presented mechanisms on cancer therapy and care.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Breast Neoplasms epidemiology
Breast Neoplasms etiology
Breast Neoplasms metabolism
Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular etiology
Carcinoma, Hepatocellular metabolism
Colorectal Neoplasms epidemiology
Colorectal Neoplasms metabolism
Endometrial Neoplasms epidemiology
Endometrial Neoplasms etiology
Endometrial Neoplasms metabolism
Female
Humans
Liver Neoplasms epidemiology
Liver Neoplasms etiology
Liver Neoplasms metabolism
Male
Metabolic Syndrome metabolism
Pancreatic Neoplasms epidemiology
Pancreatic Neoplasms etiology
Pancreatic Neoplasms metabolism
Risk Factors
Colorectal Neoplasms etiology
Metabolic Syndrome physiopathology
Models, Biological
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8600
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 25456095
- Full Text :
- https://doi.org/10.1016/j.metabol.2014.10.008