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Clinical significance of skip lymph node metastasis in gastric cancer patients.

Clinical significance of skip lymph node metastasis in gastric cancer patients.

Authors :
Kim DH
Choi MG
Noh JH
Sohn TS
Bae JM
Kim S
Source :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2015 Mar; Vol. 41 (3), pp. 339-45. Date of Electronic Publication: 2014 Nov 11.
Publication Year :
2015

Abstract

Purpose: Given the recent increase in the incidence of early gastric cancer, there is greater interest in identifying a minimally invasive therapy. The purpose of this study was to analyze the patterns of lymph node metastasis in patients with gastric cancer and to elucidate the clinical significance of skip metastasis.<br />Methods: We retrospectively analyzed patterns of lymph node metastasis (LNM) and clinicopathologic factors related to skip metastasis.<br />Results: Among 2963 patients with gastric cancer, 997 patients (33.6%) were detected as having LNM, and 27 patients (2.7%) with skip metastasis were detected among 997 patients with LNM. Skip metastasis were detected more frequently in the elderly. Compared with the N1 group, the skip metastasis group showed lower frequency of vascular invasion, and compared with the stepwise N2 group, the skip metastasis group showed smaller tumor size and a significantly higher incidence of negative lymphatic, vascular, and perineural invasion.<br />Conclusions: Currently there is no way to predict N2 station LNM including skip metastasis, D2 LN dissection for gastric cancer is thought to be the appropriate treatment, even during early stage disease. Minimally invasive therapy should be performed cautiously in consideration of possible skip metastasis.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-2157
Volume :
41
Issue :
3
Database :
MEDLINE
Journal :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Publication Type :
Academic Journal
Accession number :
25454830
Full Text :
https://doi.org/10.1016/j.ejso.2014.09.009