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Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring.
- Source :
-
Brain research [Brain Res] 2015 Jan 21; Vol. 1595, pp. 10-8. Date of Electronic Publication: 2014 Nov 01. - Publication Year :
- 2015
-
Abstract
- The objective of this study was to evaluate the effects of maternal caffeine intake on the neuromotor development of rat offspring and on acetylcholine degradation and acetylcholinesterase (AChE) expression in the hippocampus of 14-day-old infant rats. Rat dams were treated with caffeine (0.3g/L) throughout gestation and lactation until the pups were 14 days old. The pups were divided into three groups: (1) control, (2) caffeine, and (3) washout caffeine. The washout group received a caffeine solution until the seventh postnatal day (P7). Righting reflex (RR) and negative geotaxis (NG) were assessed to evaluate postural parameters as an index of neuromotor reflexes. An open-field (OF) test was conducted to assess locomotor and exploratory activities as well as anxiety-like behaviors. Caffeine treatment increased both RR and NG latency times. In the OF test, the caffeine group had fewer outer crossings and reduced locomotion compared to control, while the washout group showed increased inner crossings in relation to the other groups and fewer rearings only in comparison to the control group. We found decreased AChE activity in the caffeine group compared to the other groups, with no alteration in AChE transcriptional regulation. Chronic maternal exposure to caffeine promotes important alterations in neuromotor development. These results highlight the ability of maternal caffeine intake to interfere with cholinergic neurotransmission during brain development.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Acetylcholinesterase genetics
Age Factors
Analysis of Variance
Animals
Animals, Newborn
Body Weight physiology
Exploratory Behavior
Female
Gene Expression Regulation, Developmental drug effects
Male
Pregnancy
Rats
Rats, Wistar
Reflex physiology
Acetylcholinesterase metabolism
Caffeine toxicity
Central Nervous System Stimulants toxicity
Developmental Disabilities etiology
Hippocampus enzymology
Prenatal Exposure Delayed Effects chemically induced
Prenatal Exposure Delayed Effects pathology
Prenatal Exposure Delayed Effects physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1595
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 25451122
- Full Text :
- https://doi.org/10.1016/j.brainres.2014.10.039