Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing.

Authors :: Mueller SO
Dekant W
Jennings P
Testai E
Bois F
Source :: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2015 Dec 25; Vol. 30 (1 Pt A), pp. 4-6. Date of Electronic Publication: 2014 Oct 29.
Publication Year :: 2015
Abstract: This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project "Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics" (Predict-IV; Grant 202222). The project's overall aim was to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silico modeling, in a rapid and cost effective manner. This overview introduces the scope and overall achievements of Predict-IV.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Drug Discovery
European Union
Humans
Models, Biological
No-Observed-Adverse-Effect Level
Toxicity Tests
Cell Culture Techniques methods
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations standards
Systems Biology methods
Toxicology methods

Language :: English
ISSN :: 1879-3177
Volume :: 30
Issue :: 1 Pt A
Database :: MEDLINE
Journal :: Toxicology in vitro : an international journal published in association with BIBRA
Publication Type :: Academic Journal
Accession number :: 25450741
Full Text :: https://doi.org/10.1016/j.tiv.2014.09.016

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