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Lipid rafts, KCa/ClCa/Ca2+ channel complexes and EGFR signaling: Novel targets to reduce tumor development by lipids?
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2015 Oct; Vol. 1848 (10 Pt B), pp. 2603-20. Date of Electronic Publication: 2014 Nov 04. - Publication Year :
- 2015
-
Abstract
- Membrane lipid rafts are distinct plasma membrane nanodomains that are enriched with cholesterol, sphingolipids and gangliosides, with occasional presence of saturated fatty acids and phospholipids containing saturated acyl chains. It is well known that they organize receptors (such as Epithelial Growth Factor Receptor), ion channels and their downstream acting molecules to regulate intracellular signaling pathways. Among them are Ca2+ signaling pathways, which are modified in tumor cells and inhibited upon membrane raft disruption. In addition to protein components, lipids from rafts also contribute to the organization and function of Ca2+ signaling microdomains. This article aims to focus on the lipid raft KCa/ClCa/Ca2+ channel complexes that regulate Ca2+ and EGFR signaling in cancer cells, and discusses the potential modification of these complexes by lipids as a novel therapeutic approach in tumor development. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Calcium Channels genetics
Calcium Channels metabolism
Chloride Channels antagonists & inhibitors
Chloride Channels genetics
Chloride Channels metabolism
ErbB Receptors antagonists & inhibitors
ErbB Receptors genetics
ErbB Receptors metabolism
Fatty Acids, Omega-3 therapeutic use
Humans
Isoenzymes genetics
Isoenzymes metabolism
Linoleic Acids, Conjugated therapeutic use
Membrane Lipids chemistry
Membrane Lipids metabolism
Membrane Microdomains metabolism
Membrane Microdomains ultrastructure
Neoplasms genetics
Neoplasms metabolism
Neoplasms pathology
Potassium Channels genetics
Potassium Channels metabolism
Signal Transduction
Tumor Cells, Cultured
Antineoplastic Agents therapeutic use
Calcium metabolism
Gene Expression Regulation, Neoplastic
Membrane Lipids antagonists & inhibitors
Membrane Microdomains drug effects
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1848
- Issue :
- 10 Pt B
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 25450343
- Full Text :
- https://doi.org/10.1016/j.bbamem.2014.10.036