Back to Search
Start Over
A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes.
- Source :
-
Fertility and sterility [Fertil Steril] 2015 Jan; Vol. 103 (1), pp. 184-9. Date of Electronic Publication: 2014 Oct 22. - Publication Year :
- 2015
-
Abstract
- Objective: To examine preconception serum concentrations of perfluorooctanoic acid (PFOA) and six other PFCs in relation to gestational diabetes (GDM) risk.<br />Design: Prospective cohort with longitudinal follow-up.<br />Setting: Not applicable.<br />Patient(s): Among 501 women recruited upon discontinuing contraception for the purpose of becoming pregnant, 258 (51%) became pregnant and were eligible for the study, of which 28 (11%) reported having physician-diagnosed GDM during follow-up.<br />Intervention(s): None.<br />Main Outcome Measure(s): The odds ratios (ORs) and 95% confidence intervals (CIs) of GDM associated with each standard deviation (SD) increment of preconception serum PFOA concentration (ng/mL, log-transformed) and six other PFCs were estimated with the use of logistic regression after adjusting for age, prepregnancy body mass index, smoking, and parity conditional on gravidity.<br />Result(s): Preconception geometric mean (95% CI) PFOA concentrations (in ng/mL) were higher for women with than without GDM (3.94 [3.15-4.93] vs. 3.07 [2.83-3.12], respectively). Each SD increment in PFOA was associated with a 1.87-fold increased GDM risk (adjusted OR 1.86 [95% CI 1.14-3.02]). A slightly increased risk associated with each SD increment for the six other PFCs was observed as well (all ORs >1.0, range 1.06-1.27), although the associations were not statistically significant.<br />Conclusion(s): Our findings suggested that higher environmentally relevant concentrations of PFOA were significantly associated with an increased risk of GDM. If corroborated, these findings may be suggestive of a possible environmental etiology for GDM.<br /> (Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 103
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 25450302
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2014.10.001