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Folding and stability of integral membrane proteins in amphipols.
- Source :
-
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2014 Dec 15; Vol. 564, pp. 327-43. Date of Electronic Publication: 2014 Oct 30. - Publication Year :
- 2014
-
Abstract
- Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have proven remarkably efficient at (i) stabilizing TMPs, as compared to detergent solutions, and (ii) folding them from a denatured state to a native, functional one. The underlying physical-chemical mechanisms are discussed.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-0384
- Volume :
- 564
- Database :
- MEDLINE
- Journal :
- Archives of biochemistry and biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 25449655
- Full Text :
- https://doi.org/10.1016/j.abb.2014.10.013