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The functional Q84R polymorphism of TRIB3 gene is associated with diabetic nephropathy in Chinese type 2 diabetic patients.
- Source :
-
Gene [Gene] 2015 Jan 25; Vol. 555 (2), pp. 357-61. Date of Electronic Publication: 2014 Nov 14. - Publication Year :
- 2015
-
Abstract
- Increased oxidative stress and circulating free fatty acids (FFA) has been suggested to involve in the pathogenesis of diabetic nephropathy. TRIB3 can inhibit FFA and reactive oxygen species (ROS) stimulated podocyte production of MCP-1. Smoking increases the production of reactive oxygen species, which accelerates oxidative stress under hyperglycemia. To determine whether the Q84R polymorphism (rs2295490), alone or in combination with smoking, contributes to the development of diabetic nephropathy, a case-control study was performed in 812 Chinese patients with type 2 diabetes. Among patients, 214 had diabetic nephropathy with microalbuminuria (n=156) or overt albuminuria (n=58), and 598 did not show either of these symptoms but had diabetes for ≥10 years and were not undergoing antihypertension treatment. After adjustment for confounders, TRIB3 single-nucleotide polymorphism rs2295490 was associated with DN (OR 1.318, 95% CI 1.075, 1.653, p=0.017); smoking was also an independent risk factor for diabetic nephropathy (1.42 [1.25-2.04], p<0.001). In addition, we identified possible synergistic effects; i.e., the high-risk group (smokers with the AG+GG genotype) showed 2.13 times higher risk (1.51-3.96, p<0.001) of diabetic nephropathy than the low-risk group (nonsmokers with the AA genotype) in a multiple logistic regression analysis controlled for the confounders, but no departure from additivity was found. Our results indicate that smoking and the TRIB3 G-allele is associated with an increased risk of diabetic nephropathy, which supports the hypothesis that oxidative stress contributes to the development of diabetic nephropathy.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Alleles
China
Fatty Acids, Nonesterified metabolism
Female
Genotype
Humans
Male
Middle Aged
Oxidative Stress
Polymorphism, Single Nucleotide
Protein Serine-Threonine Kinases genetics
Reactive Oxygen Species metabolism
Risk Factors
Smoking adverse effects
Cell Cycle Proteins genetics
Diabetes Mellitus, Type 2 genetics
Diabetic Nephropathies genetics
Polymorphism, Genetic
Protein Serine-Threonine Kinases antagonists & inhibitors
Repressor Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0038
- Volume :
- 555
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 25447894
- Full Text :
- https://doi.org/10.1016/j.gene.2014.11.031