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Characterization of a new alpha-thalassemia-1 deletion in a Spanish family.
- Source :
-
Hemoglobin [Hemoglobin] 1989; Vol. 13 (2), pp. 103-16. - Publication Year :
- 1989
-
Abstract
- A new type of alpha-thalassemia-1 was characterized in one Spanish patient with Hb H disease and in her mother. The restriction map of this deletion suggests that the deletion of 22 kb has occurred on a chromosome carrying a zeta-globin triplication. The resulting chromosome lacks the alpha 2- and alpha 1-globin genes, the psi alpha 2- and psi alpha 1-globin genes, and one of the three zeta-globin genes, while the other two zeta-globin genes and the theta 1-globin gene have been retained.
Details
- Language :
- English
- ISSN :
- 0363-0269
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Hemoglobin
- Publication Type :
- Academic Journal
- Accession number :
- 2544542
- Full Text :
- https://doi.org/10.3109/03630268908998060