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BCG-induced protection: effects on innate immune memory.
- Source :
-
Seminars in immunology [Semin Immunol] 2014 Dec; Vol. 26 (6), pp. 512-7. Date of Electronic Publication: 2014 Oct 23. - Publication Year :
- 2014
-
Abstract
- The Bacille Calmette-Guerin (BCG) vaccine is the only vaccine proved to be effective against tuberculosis and it remains the most commonly used vaccine worldwide. In addition to its effects on mycobacterial diseases, an increasing body of epidemiological evidence accumulated since its introduction in 1921 shows that BCG also exerts beneficial non-specific effects ranging from protection against non-mycobacterial diseases, decreased incidence of allergic diseases, and treatment of certain malignancies. The biological substrate of these effects is mediated partly by heterologous effects on adaptive immunity, but also on the potentiation of innate immune responses through epigenetic mechanisms, a process termed 'trained immunity'. The process of trained immunity may also play a role in the beneficial effects of BCG against tuberculosis and Mycobacterium tuberculosis infection, and this could have important consequences for our quest for improving vaccination strategies.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptive Immunity
BCG Vaccine administration & dosage
BCG Vaccine chemistry
BCG Vaccine history
Clinical Trials as Topic
Epigenesis, Genetic immunology
History, 20th Century
History, 21st Century
Humans
Mycobacterium bovis chemistry
Mycobacterium bovis immunology
Tuberculosis, Pulmonary immunology
Tuberculosis, Pulmonary microbiology
BCG Vaccine immunology
Immunity, Innate drug effects
Immunologic Memory
Mycobacterium tuberculosis immunology
Tuberculosis, Pulmonary prevention & control
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3618
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Seminars in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25444548
- Full Text :
- https://doi.org/10.1016/j.smim.2014.09.006