Back to Search
Start Over
Inhibiting prolyl isomerase activity by hybrid organic-inorganic molecules containing rhodium(II) fragments.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Nov 15; Vol. 24 (22), pp. 5203-6. Date of Electronic Publication: 2014 Oct 02. - Publication Year :
- 2014
-
Abstract
- A small molecule containing a rhodium(II) tetracarboxylate fragment is shown to be a potent inhibitor of the prolyl isomerase FKBP12. The use of small molecules conjugates of rhodium(II) is presented as a general strategy for developing new protein inhibitors based on distinct structural and sequence features of the enzyme active site.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Enzyme Inhibitors pharmacology
Peptidylprolyl Isomerase antagonists & inhibitors
Peptidylprolyl Isomerase metabolism
Protein Structure, Tertiary
Rhodium pharmacology
Tacrolimus Binding Protein 1A metabolism
Enzyme Inhibitors chemistry
Rhodium chemistry
Tacrolimus Binding Protein 1A antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 24
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 25442313
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.09.068