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Identification of self-antigen-specific T cells reflecting loss of tolerance in autoimmune disease underpins preventative immunotherapeutic strategies in rheumatoid arthritis.
- Source :
-
Rheumatic diseases clinics of North America [Rheum Dis Clin North Am] 2014 Nov; Vol. 40 (4), pp. 735-52. Date of Electronic Publication: 2014 Sep 02. - Publication Year :
- 2014
-
Abstract
- Despite treatment advances, rheumatoid arthritis (RA) is still associated with significant disability, decreased work capacity, and reduced life expectancy. Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to controlling and preventing RA. Design of effective therapies requires a fundamental understanding of the critical immunopathogenetic pathways in RA. This article reviews advances in the understanding of self-antigen-specific T cells in autoimmune diseases including RA and type 1 diabetes, which bring exciting insights to the mechanisms underpinning loss of tolerance and how tolerance could be restored for disease prevention in the preclinical or recent-onset period.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Arthritis, Rheumatoid genetics
Arthritis, Rheumatoid prevention & control
Autoimmune Diseases immunology
Early Medical Intervention
HLA-DRB1 Chains genetics
Humans
Arthritis, Rheumatoid immunology
Autoantigens immunology
CD4-Positive T-Lymphocytes immunology
Diabetes Mellitus, Type 1 immunology
Self Tolerance immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-3163
- Volume :
- 40
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Rheumatic diseases clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 25437289
- Full Text :
- https://doi.org/10.1016/j.rdc.2014.07.015