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CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 genetic polymorphisms in chronic myeloid leukemia: a case-control study.
- Source :
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Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2014; Vol. 2014, pp. 875861. Date of Electronic Publication: 2014 Nov 11. - Publication Year :
- 2014
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Abstract
- Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes of GPX1, MnSOD, GSTM1, and GSTT1 polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of the GSTP1 Ile105Val gene polymorphisms may be associated with the risk of developing CML (OR = 2.5; 95% CI = 1.08-5.7; P value = 0.02), while the heterozygous genotype of the CAT C262T polymorphism seems to have a protective effect against CML (OR = 0.59, 95% CI = 0.39-0.89, P value = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded that CAT, GPX, MnSOD, GSTM1, and GSTT1 gene polymorphisms are not associated with the risk of CML. Variant genotype of the GSTP1 Ile105Val gene polymorphisms may contribute to the risk of developing CML.
- Subjects :
- Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Glutathione S-Transferase pi genetics
Humans
Male
Middle Aged
Oxidative Stress
Polymorphism, Genetic
Risk Factors
Glutathione Peroxidase GPX1
Catalase genetics
Glutathione Peroxidase genetics
Glutathione Transferase genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive enzymology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Superoxide Dismutase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 25436036
- Full Text :
- https://doi.org/10.1155/2014/875861