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CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 genetic polymorphisms in chronic myeloid leukemia: a case-control study.

Authors :
Bănescu C
Trifa AP
Voidăzan S
Moldovan VG
Macarie I
Benedek Lazar E
Dima D
Duicu C
Dobreanu M
Source :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2014; Vol. 2014, pp. 875861. Date of Electronic Publication: 2014 Nov 11.
Publication Year :
2014

Abstract

Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes of GPX1, MnSOD, GSTM1, and GSTT1 polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of the GSTP1 Ile105Val gene polymorphisms may be associated with the risk of developing CML (OR = 2.5; 95% CI = 1.08-5.7; P value = 0.02), while the heterozygous genotype of the CAT C262T polymorphism seems to have a protective effect against CML (OR = 0.59, 95% CI = 0.39-0.89, P value = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded that CAT, GPX, MnSOD, GSTM1, and GSTT1 gene polymorphisms are not associated with the risk of CML. Variant genotype of the GSTP1 Ile105Val gene polymorphisms may contribute to the risk of developing CML.

Details

Language :
English
ISSN :
1942-0994
Volume :
2014
Database :
MEDLINE
Journal :
Oxidative medicine and cellular longevity
Publication Type :
Academic Journal
Accession number :
25436036
Full Text :
https://doi.org/10.1155/2014/875861