Structural changes in the thymus in allogenic pregnancy in mice with high incidence of spontaneous and muramylpeptide-induced abortions.

Structural changes in the thymus over the course of allogenic pregnancy were studied in mice from highly fertile couples (CBA females and BALB/c males), animals with high spontaneous abortions (CBA females and DBA/2 males), and in experimental immunity-dependent pregnancy loss induced by muramyldipeptide β-heptylglycoside. Accidental involution of the thymus on days 8 and 14 of pregnancy was more pronounced in mice with high level of spontaneous embryo resorption than in females from highly fertile couples. Muramyldipeptide glycoside stimulated manifestations of thymus involution in fertile and "abortogenic" cross-breeding.