A new type of toxin A-negative, toxin B-positive Clostridium difficile strain lacking a complete tcdA gene.

Authors :: Janezic S
Marín M
Martín A
Rupnik M
Source :: Journal of clinical microbiology [J Clin Microbiol] 2015 Feb; Vol. 53 (2), pp. 692-5. Date of Electronic Publication: 2014 Nov 26.
Publication Year :: 2015
Abstract: Toxins A and B are the main virulence factors of Clostridium difficile and are the targets for molecular diagnostic tests. Here, we describe a new toxin A-negative, toxin B-positive, binary toxin CDT (Clostridium difficile transferase)-negative (A(-) B(+) CDT(-)) toxinotype (XXXII) characterized by a variant type of pathogenicity locus (PaLoc) without tcdA and with atypical organization of the PaLoc integration site.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Subjects :: ADP Ribose Transferases deficiency
Aged
Clostridioides difficile isolation & purification
Cluster Analysis
Gene Order
Genomic Islands
Humans
Male
Ribotyping
Bacterial Proteins genetics
Bacterial Toxins genetics
Clostridioides difficile classification
Clostridioides difficile genetics
Enterotoxins deficiency
Genotype

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