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Transdermal innovations in diabetes management.
- Source :
-
Current diabetes reviews [Curr Diabetes Rev] 2014; Vol. 10 (6), pp. 343-59. - Publication Year :
- 2014
-
Abstract
- Diabetes mellitus, an endocrine disorder affecting glucose metabolism, has been crippling mankind for the past two centuries. Despite the advancements in the understanding pertaining to its pathogenesis and treatment, the currently available therapeutic options are far from satisfactory. The growing diabetic population increases the gravity of the situation. The shortcomings of the conventional drug delivery systems necessitate the need to delve into other routes. On account of its merits over other routes, the transdermal approach has drawn the interest of the researchers around the world. The transdermal drug delivery systems are aimed to achieve therapeutic concentrations of the drug through skin. These systems are designed so that the drug can be delivered at a pre-determined and controlled rate. This makes it particularly conducive to treat chronic disorders like diabetes. Correspondingly, the adverse effects and inconvenience concomitant with oral and parentral route are circumvented. This article attempts to outline the development of transdermal drug delivery systems to optimize diabetes pharmacotherapy. It not only covers the transdermal approaches adopted to fine-tune insulin delivery, but also, discusses various transdermal drug delivery systems fabricated to improve the therapeutic performance of oral hypoglycaemic agents. Such formulations include the advanced drug delivery systems, namely, transferosomal gels, microemulsions, self-dissolving micropiles, nanoparticles, insulin pumps, biphasic lipid systems, calcium carbonate nanoparticles, lecithin nanoparticles; physical techniques such as iontophoresis and microneedles and, drugs formulated as transdermal patches. In addition to this, the authors have also shed light on the future prospects and patented and commercial formulations of antidiabetic agents.
- Subjects :
- Administration, Cutaneous
Diabetes Mellitus, Type 1 history
Diabetes Mellitus, Type 1 metabolism
Diabetes Mellitus, Type 2 history
Diabetes Mellitus, Type 2 metabolism
Drug Delivery Systems history
Electrophoresis
Electroporation
History, 20th Century
History, 21st Century
Humans
Hypoglycemic Agents history
Hypoglycemic Agents pharmacology
Iontophoresis
Nanoparticles
Treatment Outcome
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Type 2 drug therapy
Drug Delivery Systems methods
Hypoglycemic Agents administration & dosage
Pharmaceutical Preparations history
Skin Absorption drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6417
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current diabetes reviews
- Publication Type :
- Academic Journal
- Accession number :
- 25418713
- Full Text :
- https://doi.org/10.2174/1573399810666141124110836