Back to Search Start Over

Toward defining the anatomo-proteomic puzzle of the human brain: An integrative analysis.

Authors :
Fernandez-Irigoyen J
Labarga A
Zabaleta A
de Morentin XM
Perez-Valderrama E
Zelaya MV
Santamaria E
Source :
Proteomics. Clinical applications [Proteomics Clin Appl] 2015 Oct; Vol. 9 (9-10), pp. 796-807. Date of Electronic Publication: 2015 Feb 24.
Publication Year :
2015

Abstract

The human brain is exceedingly complex, constituted by billions of neurons and trillions of synaptic connections that, in turn, define ∼900 neuroanatomical subdivisions in the adult brain (Hawrylycz et al. An anatomically comprehensive atlas of the human brain transcriptome. Nature 2012, 489, 391-399). The human brain transcriptome has revealed specific regional transcriptional signatures that are regulated in a spatiotemporal manner, increasing the complexity of the structural and molecular organization of this organ (Kang et al. Spatio-temporal transcriptome of the human brain. Nature 2011, 478, 483-489). During the last decade, neuroproteomics has emerged as a powerful approach to profile neural proteomes using shotgun-based MS, providing complementary information about protein content and function at a global level. Here, we revise recent proteome profiling studies performed in human brain, with special emphasis on proteome mapping of anatomical macrostructures, specific subcellular compartments, and cerebrospinal fluid. Moreover, we have performed an integrative functional analysis of the protein compilation derived from these large-scale human brain proteomic studies in order to obtain a comprehensive view of human brain biology. Finally, we also discuss the potential contribution of our meta-analysis to the Chromosome-centric Human Proteome Project initiative.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1862-8354
Volume :
9
Issue :
9-10
Database :
MEDLINE
Journal :
Proteomics. Clinical applications
Publication Type :
Academic Journal
Accession number :
25418211
Full Text :
https://doi.org/10.1002/prca.201400127