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Biology and flow cytometry of proangiogenic hematopoietic progenitors cells.

Biology and flow cytometry of proangiogenic hematopoietic progenitors cells.

Authors :
Rose JA
Erzurum S
Asosingh K
Source :
Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2015 Jan; Vol. 87 (1), pp. 5-19. Date of Electronic Publication: 2014 Nov 21.
Publication Year :
2015

Abstract

During development, hematopoiesis and neovascularization are closely linked to each other via a common bipotent stem cell called the hemangioblast that gives rise to both hematopoietic cells and endothelial cells. In postnatal life, this functional connection between the vasculature and hematopoiesis is maintained by a subset of hematopoietic progenitor cells endowed with the capacity to differentiate into potent proangiogenic cells. These proangiogenic hematopoietic progenitors comprise a specific subset of bone marrow (BM)-derived cells that homes to sites of neovascularization and possess potent paracrine angiogenic activity. There is emerging evidence that this subpopulation of hematopoietic progenitors plays a critical role in vascular health and disease. Their angiogenic activity is distinct from putative "endothelial progenitor cells" that become structural cells of the endothelium by differentiation into endothelial cells. Proangiogenic hematopoietic progenitor cell research requires multidisciplinary expertise in flow cytometry, hematology, and vascular biology. This review provides a comprehensive overview of proangiogenic hematopoietic progenitor cell biology and flow cytometric methods to detect these cells in the peripheral blood circulation and BM.<br /> (© 2014 International Society for Advancement of Cytometry.)

Details

Language :
English
ISSN :
1552-4930
Volume :
87
Issue :
1
Database :
MEDLINE
Journal :
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Publication Type :
Academic Journal
Accession number :
25418030
Full Text :
https://doi.org/10.1002/cyto.a.22596