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Biology and flow cytometry of proangiogenic hematopoietic progenitors cells.
Biology and flow cytometry of proangiogenic hematopoietic progenitors cells.
- Source :
-
Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2015 Jan; Vol. 87 (1), pp. 5-19. Date of Electronic Publication: 2014 Nov 21. - Publication Year :
- 2015
-
Abstract
- During development, hematopoiesis and neovascularization are closely linked to each other via a common bipotent stem cell called the hemangioblast that gives rise to both hematopoietic cells and endothelial cells. In postnatal life, this functional connection between the vasculature and hematopoiesis is maintained by a subset of hematopoietic progenitor cells endowed with the capacity to differentiate into potent proangiogenic cells. These proangiogenic hematopoietic progenitors comprise a specific subset of bone marrow (BM)-derived cells that homes to sites of neovascularization and possess potent paracrine angiogenic activity. There is emerging evidence that this subpopulation of hematopoietic progenitors plays a critical role in vascular health and disease. Their angiogenic activity is distinct from putative "endothelial progenitor cells" that become structural cells of the endothelium by differentiation into endothelial cells. Proangiogenic hematopoietic progenitor cell research requires multidisciplinary expertise in flow cytometry, hematology, and vascular biology. This review provides a comprehensive overview of proangiogenic hematopoietic progenitor cell biology and flow cytometric methods to detect these cells in the peripheral blood circulation and BM.<br /> (© 2014 International Society for Advancement of Cytometry.)
- Subjects :
- Antigens, CD genetics
Antigens, CD metabolism
Bone Marrow metabolism
Cell Differentiation
Cell Lineage physiology
Cytokines genetics
Cytokines metabolism
Endothelial Cells metabolism
Endothelium, Vascular metabolism
Flow Cytometry
Gene Expression
Hemangioblasts metabolism
Humans
Receptors, Vascular Endothelial Growth Factor genetics
Receptors, Vascular Endothelial Growth Factor metabolism
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor A metabolism
Endothelial Cells cytology
Endothelium, Vascular cytology
Hemangioblasts cytology
Hematopoiesis physiology
Neovascularization, Physiologic
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4930
- Volume :
- 87
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cytometry. Part A : the journal of the International Society for Analytical Cytology
- Publication Type :
- Academic Journal
- Accession number :
- 25418030
- Full Text :
- https://doi.org/10.1002/cyto.a.22596